Dr. Shisong Jiang
Dr. Shisong Jiang is a clinician-turned scientist. He received his PhD degree from London School of Hygiene and Tropical Medicine in 2000. After that, he did 4.5 year’s postdoctoral research at Harvard Medical School /Dana-Farber Cancer Institute in USA before working at University of Oxford working as a Principle Investigator/Clinical Research Fellow in the Department of Oncology.
One of his major contributions to science is his pioneer work to show that overlapping peptides of a viral or tumour antigen have advantages over the protein from of the same antigen and can be processed by immune system to activate both killer and helper T cells. This innovated work has applications in vaccine and diagnostic development. Since then, numerous different clinical trials around the world have been launched and the concept has been validated by promising efficacy and safety data. As a result of his work, a spinout company, Oxford Vacmedix Ltd has formed from the University of Oxford to develop cost-effective vaccines against tumours and infectious diseases.
Another novel discovery by his team is the identification of an inflammatory biomarker, inflammation enhancer (IE). IE is strongly correlated with the mortality of severe sepsis in intensive care unit (ICU) and with chronic inflammatory diseases like rheumatoid arthritis. A diagnostic and therapeutic method is being developed to identify and remove the toxic IE.